Pharmaceutical manufacturingRestoring Laminar-Flow Modules for Vaccine Production
A pharmaceutical manufacturer needed large laminar-flow modules recovered after installation deficiencies produced repeated HEPA failures and leakage around the module frames.
The challenge
The modules had been installed by a contractor without the specialized experience required for this type of clean-air system. Numerous filters failed integrity testing, and heavy applications of silicone had been used in an unsuccessful attempt to stop leakage. The manufacturer could not release the modules for production until the airflow system could demonstrate acceptable performance.
Micron's response
- Mapped the failure locations to distinguish filter leaks from frame and installation leakage.
- Removed the HEPA filters and the excessive sealant left from earlier repair attempts.
- Accessed and sealed the module framing from the interior so the leakage path was addressed at its source.
- Installed new filters and repeated integrity testing across the restored assemblies.
The outcome
The repaired modules achieved passing HEPA-integrity results. The manufacturer was able to release the units to production for a critical COVID-19 vaccine program.


